Critical Appraisal: Rejuvenation of Aged Human Skin by Broadband Light Treatment

February 11, 2025

Citation: Chang AL, Bitter PH Jr, Qu K, Lin M, Rapicavoli NA, Chang HY. Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study. J Invest Dermatol. 2013 Feb;133(2):394-402. doi: 10.1038/jid.2012.287. Epub 2012 Aug 30. Erratum in: J Invest Dermatol. 2013 Jun;133(6):1691. PMID: 22931923; PMCID: PMC3547222.

Study Overview

This study, published in the Journal of Investigative Dermatology, investigates whether broadband light (BBL) treatment can reverse gene expression patterns associated with skin aging. The researchers analyzed skin samples from aged and young individuals and found that BBL treatment significantly altered the expression of over 1,200 genes, making them resemble those of younger skin.

Key Findings

Aging alters the expression of over 2,200 coding and noncoding RNAs (molecules that don’t make proteins but help regulate gene activity and cell functions) in human skin.
After BBL treatment, 1,293 of these genes showed a “rejuvenated” expression pattern, meaning they became more similar to youthful skin.
BBL treatment appeared to enhance skin appearance by reducing wrinkles, pigmentation irregularities, and erythema.
Histological analysis (studying tissue samples under a microscope) showed reduced elastotic fibers and increased epidermal thickness post-treatment.
The molecular rejuvenation included changes in genes linked to aging and longevity, such as IGF1R, ZMPSTE24, and EIF4G1.

Before & Afters

Take-Home Messages for Patients

Can BBL Actually Prevent Aging?

Yes, regular BBL treatments may help keep your skin looking younger for longer. Evidence suggests that BBL can restore youthful gene expression and delay the onset of fine lines, wrinkles, and pigmentation.

Who Should Consider BBL?

Younger individuals (20s–40s) wanting to maintain youthful skin.
Those with sun damage (pigmentation, uneven skin tone).
Patients post-facelift or laser treatments who want to maintain results.

How Often Do You Need Treatments?

2–4 treatments per year for optimal results.
Quarterly sessions may provide the best age-prevention benefits.

How Does It Compare to Other Treatments?

BBL vs. Laser Resurfacing: BBL is non-ablative (no peeling), while lasers remove skin layers.
BBL vs. Microneedling: BBL improves pigmentation and texture, while microneedling boosts collagen.
BBL vs. Chemical Peels: BBL evens out skin tone more effectively with minimal downtime.

Is BBL Safe?

Yes, but choosing an experienced provider is key—incorrect settings can cause hyperpigmentation or burns.

The Bottom Line

Forever Young BBL™ may slow down skin aging, making it a powerful addition to your anti-aging routine. It’s not just about correcting wrinkles—it’s about preventing them in the first place.